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 "citation": "**BibTeX:**\n\n```txt\n@article{\n  doi:10.1126/sciadv.abm6638,\n  author = {Xu Feng  and Mengfan Tang  and Merve Dede  and Dan Su  and Guangsheng Pei  and Dadi Jiang  and Chao Wang  and Zhen Chen  and Mi Li  and Litong Nie  and Yun Xiong  and Siting Li  and Jeong-Min Park  and Huimin Zhang  and Min Huang  and Klaudia Szymonowicz  and Zhongming Zhao  and Traver Hart  and Junjie Chen },\n  title = {Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors},\n  journal = {Science Advances},\n  volume = {8},\n  number = {19},\n  pages = {eabm6638},\n  year = {2022},\n  doi = {10.1126/sciadv.abm6638},\n  URL = {https://www.science.org/doi/abs/10.1126/sciadv.abm6638},\n  eprint = {https://www.science.org/doi/pdf/10.1126/sciadv.abm6638},\n  abstract = {Exploiting cancer vulnerabilities is critical for the discovery of anticancer drugs. However, tumor suppressors cannot be directly targeted because of their loss of function. To uncover specific vulnerabilities for cells with deficiency in any given tumor suppressor(s), we performed genome-scale CRISPR loss-of-function screens using a panel of isogenic knockout cells we generated for 12 common tumor suppressors. Here, we provide a comprehensive and comparative dataset for genetic interactions between the whole-genome protein-coding genes and a panel of tumor suppressor genes, which allows us to uncover known and new high-confidence synthetic lethal interactions. Mining this dataset, we uncover ess",
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